Expression data of cHL cell lines after KLF4 activation

ABSTRACT: Characteristic extinguishing of B-cell phenotype in cHL is believed to be a result of transcription factor network deregulation due to the overexpression of repressor proteins ID2 and ABF-1. KLF4 is a versatile transcription factor, participating in regulation of differentiation processes in various tissues. Epigenetic silencing of KLF4 in cHL hints that KLF4 is involved in the complex mechanism of extinguishing of B-cell phenotype in cHL. To clarify this issue we investigated transcriptome changes, induced by KLF4 activation in two cHL cell lines KM-H2 and L428. KM-H2-KLF-ER and L428-KLF-ER cells were incubated with 200 µM 4-OHT or vehicle (ethanol). The experiment was done twice. After 24 h, total RNA was isolated with RNeasy mini kit (QIAGEN). Microarray analyses were performed using 2

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Wirth 

PROVIDER: E-GEOD-21296 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress