Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of human multiple myeloma

ABSTRACT: We have used genome-wide methylation microarrays to analyze differences in CpG methylation patterns in cells relevant to the pathogenesis of myeloma plasma cells, including B cells, normal plasma cells, MGUS, presentation myeloma, and plasma cell leukemia (PCL). We show that methylation patterns in these cell types are capable of distinguishing non-malignant from malignant cells and that the main reason for this difference is hypomethylation of the genome at the transition from MGUS to presentation myeloma. In addition, gene-specific hypermethylation was evident at the myeloma stage. Differential methylation was also evident at the transition from myeloma to PCL with re-methylation of the genome, specifically of genes involved in cell-cell signaling and cell adhesion, which may contribute

ORGANISM(S): Homo sapiens

SUBMITTER: Gareth Morgan 

PROVIDER: E-GEOD-21304 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress