Cell-Specific Determinants of PPARg Function in Adipocytes and Macrophages

ABSTRACT: The nuclear receptor Peroxisome Proliferator Activator Receptor (PPAR ) is the target of antidiabetic thiazolidinedione drugs, which improve insulin resistance but have side-effects that limit widespread use. PPAR is required for adipocyte differentiation, but is also expressed in other cell types, notably macrophages, where it influences atherosclerosis, insulin resistance, and inflammation. A central question is whether PPAR binding in macrophages occurs at the same or different genomic locations compared to adipocytes. Here, utilizing chromatin immunoprecipitation and high throughput sequencing (ChIP-seq), we demonstrate that PPAR cistromes in adipocytes and macrophages are predominantly cell type specific. In macrophages, PPAR colocalizes with the hematopoietic transcription fact

ORGANISM(S): Mus musculus

SUBMITTER: Mitchell Lazar 

PROVIDER: E-GEOD-21314 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress