Genome-wide analysis of alternative splicing points to novel leukemia-relevant genes in acute myeloid leukemia.

ABSTRACT: Alternative mRNA splicing represents an effective mechanism of regulating gene function and is a key element to increase the coding capacity of the human genome. Today, an increasing number of reports illustrates that aberrant splicing events are common and functionally important for cancer development. However, more comprehensive analyses are warranted to get novel insights into the biology underlying malignancies like e.g. acute myeloid leukemia (AML). Here, we performed a genome-wide screening of splicing events in AML using an exon microarray platform. We analyzed complex karyotype and core binding factor (CBF) AML cases (n=64) in order to evaluate the ability to detect alternative splicing events distinguishing distinct leukemia subgroups. Testing different commercial and open source

ORGANISM(S): Homo sapiens

SUBMITTER: Anna Dolnik 

PROVIDER: E-GEOD-21337 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress