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Maternal influences on the transmission of leukocyte gene expression profiles in population samples (mother and child)

ABSTRACT: This study contrasts the expression profiles of peripheral blood leukocytes from third trimester pregnant mothers, with cord blood leukocytes from their newborn children. It is a companion to (GSE21311). After normalization for RNA integrity, major principal components of the variation were found to distinguish individuals. Transmission of gene expression profiles from mother to child was documented, along with differences between gestational diabetic, obese, and normal weight mothers and their children. 56 individulas (Brisbane, Australia) were sampled for the mother-newborn study, under informed consent. 19 mothers sample were collected in the last month of pregnancy (between 30th and 36th week of pregnancy) and 37 cord blood samples were obtained at birth from newborn babies. Mothers having BMI values over 30 before pregnancy were classified as obese. From the 37 newborn babies, 10 were born to obese mothers, 8 to gestational diabetic mothers (with a wide range of body mass indices), and 19 to normal-weight mothers. There were 16 mother-newborn pairs in the dataset. RNA from each was hybridized to an Illumina HT12 array.

ORGANISM(S): Homo sapiens

SUBMITTER: Jinhee Kim 

PROVIDER: E-GEOD-21342 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Maternal influences on the transmission of leukocyte gene expression profiles in population samples from Brisbane, Australia.

Mason Elizabeth E   Tronc Graham G   Nones Katia K   Matigian Nick N   Kim Jinhee J   Aronow Bruce J BJ   Wolfinger Russell D RD   Wells Christine C   Gibson Greg G  

PloS one 20101231 12

Two gene expression profiling studies designed to identify maternal influences on development of the neonate immune system and to address the population structure of the leukocyte transcriptome were carried out in Brisbane, Australia. In the first study, a comparison of 19 leukocyte samples obtained from mothers in the last three weeks of pregnancy with 37 umbilical cord blood samples documented differential expression of 7,382 probes at a false discovery rate of 1%, representing approximately h  ...[more]

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