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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiling of three type of grade II gliomas

ABSTRACT: In this study we performed gene expression profiling of 14 cases of grade II gliomas. The results of these analysis were used in unsupervised analyses to compare correlations between the histological subtype of grade II gliomas and gene expression profiles Total RNA was isolated from 14 tumor tissue of patients, which included 5 astrocytomas WHO grade II (T2), 5 oligodendro-gliomas WHO grade II (T2) and 4 ependymomas WHO grade II (T2) samples, in additional to 4 normal tissues. The genome-wide expression analysis was first performed by directly comparing the expression profile of highly enriched different kinds of grade II gliomas and normal tissues, we then applied various data-mining methods to process the 14 different types of grade II gliomas tissues sample.

ORGANISM(S): Homo sapiens

SUBMITTER: Zhiqiang Yao

PROVIDER: E-GEOD-21354 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling in human high-grade astrocytomas.

Liu Zhongyu Z Yao Zhiqiang Z Li Chao C Lu Yicheng Y Gao Chunfang C

Comparative and functional genomics 20110807

Diffuse astrocytoma of (WHO grade II) has a tendency to progress spontaneously to anaplastic astrocytoma (WHO grade III) and/or glioblastoma (WHO grade IV). However, the molecular basis of astrocytoma progression is still poorly understood. In current study, an essential initial step toward this goal is the establishment of the taxonomy of tumors on the basis of their gene expression profiles. We have used gene expression profiling, unsupervised (hierarchal cluster (HCL) and principal component ...[more]

PMID: 21836821

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