Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Human medulloblastoma

ABSTRACT: Whole-genome screening of DNA-copy number changes by array-based or matrix comparative genomic hybridization (matrix-CGH). Tumor DNA was hybridized against a single standard reference DNA-pool of the opposite sex than the patient. Every experiment was performed as dye-swap.

ORGANISM(S): Homo sapiens

SUBMITTER: Frank Mendrzyk

PROVIDER: E-GEOD-2139 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma.

Mendrzyk Frank F Radlwimmer Bernhard B Joos Stefan S Kokocinski Felix F Benner Axel A Stange Daniel E DE Neben Kai K Fiegler Heike H Carter Nigel P NP Reifenberger Guido G Korshunov Andrey A Lichter Peter P

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051201 34

<h4>Purpose</h4>Medulloblastoma is the most common malignant brain tumor in children. Despite multimodal aggressive treatment, nearly half of the patients die as a result of this tumor. Identification of molecular markers for prognosis and development of novel pathogenesis-based therapies depends crucially on a better understanding of medulloblastoma pathomechanisms.<h4>Patients and methods</h4>We performed genome-wide analysis of DNA copy number imbalances in 47 medulloblastomas using comparati ...[more]

PMID: 16314645

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Dataset Information

Human medulloblastoma

Publications

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma.

Similar Datasets

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