Genome-wide mapping of cytosine methylation revealed dynamic DNA methylation patterns associated with rice centromeres

ABSTRACT: Specification and propagation of the centromeres of eukaryotic chromosomes is determined by epigenetic mechanisms. Unfortunately, the epigenetic characteristics of centromeric DNA and chromatin are difficult to define because the centromeres are composed of highly repetitive DNA sequences in most eukaryotic species. Several rice centromeres have been fully sequenced, making rice an excellent model for centromere research. We conducted genome-wide mapping of cytosine methylation using methylcytosine immunoprecipitation combined with Illumina sequencing. The DNA sequences in the core domains of rice Cen4, Cen5, and Cen8 showed elevated methylation levels compared to the sequences in the pericentromeric regions. In addition, elevated methylation levels were associated with the DNA sequences i

ORGANISM(S): Oryza sativa

SUBMITTER: Yufeng Wu 

PROVIDER: E-GEOD-21414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress