Transcription profiling of human oesophageal cells stimulated with a low pH environment
Ontology highlight
ABSTRACT:
Missing data files: GSM38763.CEL (Time 0 mins rep 1), GSM38764.CEL (Time 0 mins rep 2), GSM38771.CEL (Time 240 mins rep 1), and GSM38772.CEL (Time 240 mins rep 2).
ORGANISM(S): Homo sapiens
SUBMITTER: Shane Duggan
PROVIDER: E-GEOD-2144 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Low pH induces co-ordinate regulation of gene expression in oesophageal cells.
Duggan Shane P SP Gallagher William M WM Fox Edward J P EJ Abdel-Latif Mohammed M MM Reynolds John V JV Kelleher Dermot D
Carcinogenesis 20050819 2
The development of gastro-oesophageal reflux disease (GORD) is known to be a causative risk factor in the evolution of adenocarcinoma of the oesophagus. The major component of this reflux is gastric acid. However, the impact of low pH on gene expression has not been extensively studied in oesophageal cells. This study utilizes a transcriptomic and bioinformatic approach to assess regulation of gene expression in response to low pH. In more detail, oesophageal adenocarcinoma cell lines were expos ...[more]
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