NRG1/ERBB3 signaling in melanocyte Melan-Ink4a cells

ABSTRACT: Neuregulin (NRG) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression. Here, we show that NRG1/ERBB3 signaling inhibits melanocyte (MC) maturation and promotes undifferentiated, migratory and proliferative cellular characteristics. Embryonic analyses demonstrated that initial MC specification and distribution were not dependent on ERBB3 signaling. However NRG1/ERBB3 signaling was both necessary and sufficient to inhibit differentiation of later stages of MC development in culture. Analysis of tissue arrays of human melanoma samples suggests that ERBB3 signaling may also contribute to metastatic progression of melanoma as ERBB3 was phosphorylated in primary tumors compared with ne

ORGANISM(S): Mus musculus

SUBMITTER: William Pavan 

PROVIDER: E-GEOD-21463 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress