Nucleotide composition-linked divergence of vertebrate core promoter architecture

ABSTRACT: Transcription initiation involves the recruitment of basal transcription factors to the core promoter. A variety of core promoter elements exists, however for most of these motifs the distribution across species is unknown. Here we report on the comparison of human and amphibian promoter sequences. We have used oligo-capping in combination with deep sequencing to determine transcription start sites in Xenopus tropicalis. To systematically predict regulatory elements we have developed a de novo motif finding pipeline using an ensemble of computational tools. A comprehensive comparison of human and amphibian promoter sequences revealed both similarities and differences in core promoter architecture. Some of the differences stem from a highly divergent nucleotide composition of Xenopus and hu

ORGANISM(S): Xenopus (Silurana) tropicalis

SUBMITTER: Gert Jan Veenstra 

PROVIDER: E-GEOD-21482 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress