Changes in bone marrow resident monocyte gene expression upon induction of ischemia

ABSTRACT: There is considerable interest in the potential of cell-based approaches to mediate therapeutic angiogenesis for acute and chronic vascular syndromes. Using a mouse model of HLI, we showed previously that adoptive transfer of a small number of donor monocytes enhanced revascularization significantly. Herein, we provide data suggesting that the BM resident monocytes sense systemic signals that influence their future functional capacity. Specifically, following induction of distant ischemia, the angiogenic capacity of BM resident monocytes is reduced markedly. We provide evidence that G-CSF and IL-6 represent such conditioning signals. Systemic levels of G-CSF and IL-6 are increased significantly following induction of HLI. Accordingly, BM resident monocytes from ischemic mice exhibited incr

ORGANISM(S): Mus musculus

SUBMITTER: Alyssa Gregory 

PROVIDER: E-GEOD-21509 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress