Clinical Significance of Osteoprotegerin Expression in Human Colorectal Cancer

ABSTRACT: Purpose: This study aimed to identify a novel biomarker or a target of treatment for colorectal cancer (CRC). Experimental Design: The expression profiles of cancer cells in 104 patients with CRC were examined using laser microdissection and oligonucleotide microarray analysis. Overexpression in CRC cells especially in patients with distant metastasis was a prerequisite to select candidate genes. The mRNA expression of candidate gene was investigated by quantitative reversetranscription polymerase chain reaction (RT-PCR) in 77 patients as a validation study. We analyzed the protein expression and localization of the candidate gene by immunohistochemical study, and investigated the relationship between the expression and the clinicopathological feature in 274 CRC patients. Results: We ident

ORGANISM(S): Homo sapiens

DISEASE(S): none

SUBMITTER: Kaoru Mogushi 

PROVIDER: E-GEOD-21510 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress