Direct Reprogramming of Fibroblasts into Epiblast Stem Cells

ABSTRACT: Embryonic stem cells (ESCs), which are derived from the primitive ectoderm of pre-implantation blastocysts, are pluripotent cells and can thus contribute to the formation of all somatic cell lineages in chimeric animals. Similarly, epiblast stem cells (EpiSCs), which are derived from epiblast tissue of post-implantation embryos, are also pluripotent and can give rise to derivatives of all three germ layers in teratoma assays. Introduction of the four transcription factors Oct4/Sox2/Klf4/c-Myc into somatic cells has been shown to generate induced pluripotent stem cells (iPSCs). iPSCs exhibit ESC-like properties and are virtually identical to ESCs with respect to a number of charactertistics. However, generation of EpiSC-like cells by direct reprogramming of somatic cells using these

ORGANISM(S): Mus musculus

SUBMITTER: Marcos Arauzo-Bravo 

PROVIDER: E-GEOD-21516 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress