Differential gene expression profiles of long bones of telomerase deficient mice (G3-mTERC-/-)

ABSTRACT: Telomere shortening due to telomerase deficiency leads to accelerated senescence of human skeletal (mesenchymal) stem cells (MSC) in vitro. In order to study the role of telomere shortening in vivo, we studied the phenotype of telomerase deficient mice caused by absence of telomerase RNA component (TERC-/-). TERC-/- exhibited accelerated age-related bone loss starting at 3 months of age and during 12 months follow up. Bone histomorphometry revealed decreased mineralized surface and bone formation rate as well as increased osteoclast number and size in TERC-/-. Also, serum total deoxy-pyridinoline (tDPD) was increased in TERC-/-. MSC isolated from TERC-/- exhibited intrinsic defects with reduced total number, lower proliferation rate, decreased expression of osteoblastic (OB) differentiat

ORGANISM(S): Mus musculus

SUBMITTER: Basem Abdallah 

PROVIDER: E-GEOD-21523 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress