The relationship between the gene expression profile in the synovium of RA patients at baseline and the clinical response to infliximab treatment

ABSTRACT: Background: Although the use of TNF inhibitors has fundamentally changed the way rheumatoid arthritis (RA) is treated, not all patients respond well. It is desirable to facilitate the identification of responding and non-responding patients prior to treatment, not only to avoid unnecessary treatment but also for financial reasons. In this work we have investigated the transcriptional profile of synovial tissue sampled from RA patients before anti-TNF treatment with the aim to identify biomarkers predictive of response. Methodology/Principal Findings: Synovial tissue samples were obtained by arthroscopy from 62 RA patients before the initiation of infliximab treatment. RNA was extracted and gene expression profiling was performed using an in-house spotted long oligonucleotide array covering

ORGANISM(S): Homo sapiens

SUBMITTER: Johan Lindberg 

PROVIDER: E-GEOD-21537 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress