The Effects of Aging on the Molecular and Cellular Composition of the Prostate Microenvironment

ABSTRACT: Advancing age is associated with substantial increases in the incidence rates of common diseases affecting the prostate including benign prostatic hyperplasia (BPH) and prostate carcinoma. However, to date, there is no established molecular explanation for the age-dependent increases in these pathologies. The prostate is comprised of a functional secretory epithelium supported by a spectrum of cell types and structural elements comprising the stroma. As reciprocal interactions between epithelium and stromal constituents are essential for normal organogenesis and serve to maintain normal functions, discordance within the stromal could permit or promote disease processes. In this study we sought to identify aging-associated alterations in the mouse prostate that could influence pathology. We

ORGANISM(S): Mus musculus

SUBMITTER: Ilsa Coleman 

PROVIDER: E-GEOD-21542 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress