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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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A constitutively activated form of the p110 beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice

ABSTRACT: The global gene expression profiles of ventral prostates of wild type mice and p110 beta transgenic mice. normal prostate vs. prostate cancer induced by the overexpression of the active allele of p110 beta

ORGANISM(S): Mus musculus

SUBMITTER: S Lee

PROVIDER: E-GEOD-21543 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice.

Lee Sang Hyun SH Poulogiannis George G Pyne Saumyadipta S Jia Shidong S Zou Lihua L Signoretti Sabina S Loda Massimo M Cantley Lewis Clayton LC Roberts Thomas M TM

Proceedings of the National Academy of Sciences of the United States of America 20100601 24

Recent work has shown that ablation of p110beta, but not p110alpha, markedly impairs tumorigenesis driven by loss of phosphatase and tensin homolog (PTEN) in the mouse prostate. Other laboratories have reported complementary data in human prostate tumor lines, suggesting that p110beta activation is necessary for tumorigenesis driven by PTEN loss. Given the multiple functions of PTEN, we wondered if p110beta activation also is sufficient for tumorigenesis. Here, we report that transgenic expressi ...[more]

PMID: 20534477

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