Systems genetics approach to low dose radiation sensitivity in BXD recombinant inbred mice

ABSTRACT: The immune system illustrates the challenges of assigning risk to low dose radiation (LDR) exposure in a population. While high radiation doses clearly suppress immune function, a number of studies have shown that LDR affects immune cell subpopulations in ways that could be beneficial. In the intact organism, defining the consequences of LDR is further complicated by the impact of genetic background, particularly in systems such as the immune system for which both radiosensitivity and genetic effects are profound. We employed a systems genetics approach to test for heritable differences in LDR responses. Mice from 39 BXD recombinant inbred (RI) strains were exposed to 10cGy gamma radiation to determine effects on immune function and oxidative stress 48h after irradiation. LDR significantl

ORGANISM(S): Mus musculus

SUBMITTER: Rachel Lynch 

PROVIDER: E-GEOD-21562 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress