Affymetrix SNP array data for Burkitt lymphoma samples

ABSTRACT: For sporadic Burkitt lymphoma (BL) few genetic lesions are known besides the pathognomonic IG-MYC translocations. Thirtynine molecularly-defined BL were analyzed with high-resolution single-nucleotide polymorphism chips for genomic imbalances and uniparental disomy (UPD). Imbalances were correlated to transcript profiling and selected miRNA analysis. Translocations affecting the MYC locus were studied by fluoresence in situ hybridization. We detected 528 copy number changes, defining 29 recurrently imbalanced regions. 518 regions of UPD were found, but these were rarely recurrent. Combined imbalance mapping and transcript profiling revealed a profound correlation between copy number and expression. Several recurrent imbalances affected the MYC pathway: The miRNA-supercluster 17-92 was freq

ORGANISM(S): Homo sapiens

SUBMITTER: Rene Scholtysik 

PROVIDER: E-GEOD-21597 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress