Transcription profiling of post-mortem human brain to investigate gender specific gene expression

ABSTRACT: Gender differences in brain development and in the prevalence of neuropsychiatric disorders such as depression have been reported. Gender differences in human brain might be related to patterns of gene expression. Microarray technology is one useful method for investigation of gene expression in brain. We investigated gene expression, cell types, and regional expression patterns of differentially expressed sex chromosome genes in brain. We profiled gene expression in male and female dorsolateral prefrontal cortex, anterior cingulate cortex, and cerebellum using the Affymetrix oligonucleotide microarray platform. Differentially expressed genes between males and females on the Y chromosome (DBY, SMCY, UTY, RPS4Y, and USP9Y) and X chromosome (XIST) were confirmed using real-time PCR measureme

ORGANISM(S): Homo sapiens

SUBMITTER: Marquis Vawter 

PROVIDER: E-GEOD-2164 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress