Temporal characterization of the organ-specific Rhipicephalus microplus transcriptional response to Anaplasma marginale infection

ABSTRACT: In addressing R. microplus - A. marginale interactions, we propose and test three linked hypotheses. The first is that the tick gene response is organ specific: the midgut gene regulation is unique during feeding and during acquisition of A. marginale as compared to the salivary gland. This distinction is relevant as the two organs serve very different roles in the transmission biology of A. marginale with early survival and replication within the midgut epithelium, composed of highly phagocytic cells, required for initial colonization while a second round of replication in the salivary gland acini, composed of highly secretory cells, is required for transmission of an infectious dose in the saliva. Importantly, both the midgut epithelium and salivary glands have been identified as sepa

ORGANISM(S): Rhipicephalus microplus

SUBMITTER: Ricardo Mercado-Curiel 

PROVIDER: E-GEOD-21690 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress