Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors

ABSTRACT: Aberrant DNA methylation (DNAm) was first linked to cancer over 25 years ago. Since then, many studies have associated hypermethylation of tumour suppressor genes and hypomethylation of oncogenes to the tumourigenic process. However, most of these studies have been limited to the analysis of promoters and CpG islands (CGIs). Recently, new technologies for whole-genome DNAm (methylome) analysis have been developed, enabling unbiased analysis of cancer methylomes. Using MeDIP-seq, we report a sequencing-based comparative methylome analysis of malignant peripheral nerve sheath tumours (MPNST), benign Neurofibromas and normal Schwann cells. Analysis of these methylomes revealed a complex landscape of DNAm alterations. Contrary to the current dogma, significant global hypomethylation was not ob

ORGANISM(S): Homo sapiens

SUBMITTER: Gareth Wilson 

PROVIDER: E-GEOD-21714 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress