A large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 transcriptional response

ABSTRACT: Recently, more than a thousand large intergenic non-coding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identification of lincRNAs that are regulated by p53. One of these lincRNAs (lincRNA-p21) serves as a repressor in p53-dependent transcriptional responses. Inhibition of lincRNA-p21 affects the expression of hundreds of gene targets enriched for genes normally repressed by p53. The observed transcriptional repression by lincRNA-p21 is mediated through the physical association with hnRNP-K. This interaction is required for proper genomic localization of hnRNP-K at repressed genes and regulation of p53 mediated apoptosis. We propose a model whereby transcr

ORGANISM(S): Mus musculus

SUBMITTER: Mitchell Guttman 

PROVIDER: E-GEOD-21761 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress