Zucker Diabetic Fatty (ZDF) Rat Study - Diaphragm vs. Sternohyoid

ABSTRACT: Type 2 diabetes differs from type 1 diabetes in its pathogenesis. Type 1 diabetic diaphragm has altered gene expression which includes lipid and carbohydrate metabolism, ubiquitination and oxidoreductase activity. The objectives of the present study were to assess respiratory muscle gene expression changes in type 2 diabetes and to determine whether they are greater for the diaphragm than an upper airway muscle. Diaphragm and sternohyoid muscle from Zucker diabetic fatty (ZDF) rats were analyzed with Affymetrix gene expression arrays. The two muscles had 97 and 102 genes, respectively, with at least ±1.5-fold significantly changed expression with diabetes, and these were assigned to gene ontology groups based on over-representation analysis. Several significantly changed groups were common

ORGANISM(S): Rattus norvegicus

SUBMITTER: Erik van Lunteren 

PROVIDER: E-GEOD-21791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress