Gene expression on 144 arrays representing 125 workers exposed to a range of benzene exposures

ABSTRACT: Human toxicogenomic studies to date have been of limited size, have mainly addressed exposures at the upper end of typical ranges of human exposure, and have often lacked precise, individual estimates of exposure. Previously, we identified genes associated with exposure to high (>10 ppm) levels of the leukemogen, benzene, through transcriptomic analyses of blood cells from small numbers of occupationally exposed workers. Here, we have expanded the study to 125 workers exposed to a wide range of benzene levels, including <1 ppm. Study design, and analysis with a mixed effects model, removed sources of biological and experimental variability and revealed highly significant widespread perturbation of gene expression at all exposure levels. Benzene is an established cause of acute myeloid leuk

ORGANISM(S): Homo sapiens

SUBMITTER: Alan Hubbard 

PROVIDER: E-GEOD-21862 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress