Expression data from Saccharomyces cerevisiae Dnup60, Dada2, and Dnup60 Dada2 cells

ABSTRACT: In Saccharomyces cerevisiae, specific genes physically relocate from the nucleoplasm to the nuclear periphery concomitant with transcriptional activation, where they associate with the nuclear pore complex (NPC). We took a genomics approach in order to gain insight into the universality and physiological relevance of the interaction between active genes and the NPC. Using synthetic genetic array (SGA) approach, we identified interactions between components of the SAGA histone acetyltransferase complex and the Mlp and Nup60 subunits of the NPC. Cells lacking these SAGA and NPC components display growth defects under optimal growth conditions, in which cells are grown on rich medium containing the preferred sugar glucose as a carbon source and incubated at their optimal temperature. That

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Kristine Willis 

PROVIDER: E-GEOD-21870 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress