Transcriptional profiling of yeast transcription factor deletion strains (rox1, xbp1 or phd1) and wild-type strains in response to hydrogen peroxide or butanol

ABSTRACT: The goal of this study was to determine the effect of transcription factor deletions on the expression of subtelomeric genes in the presence of environmental stimuli. This study is a component of a larger study, which identified that environment-responsive transcription factors bind proto-silencer elements and regulate subtelomeric silencing. Subtelomeric chromatin is subject to evolutionarily conserved complex epigenetic regulation and is implicated in numerous aspects of cellular function including formation of heterochromatin, regulation of different stress response pathways, and control of lifespan. Subtelomeric DNA is characterized by the presence of specific repeated segments that serve to propagate silencing activities or to protect chromosomal regions from spreading epigenetic co

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Jennifer Smith 

PROVIDER: E-GEOD-21926 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress