Expression data from bone marrow derived- and tumor induced- CD11b+ MDSC

ABSTRACT: Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF, G-CSF, and IL-6 allowed a rapid generation of MDSCs from precursors present in mouse and human bone marrow (BM). BM-MDSCs induced by GM-CSF+IL-6 possessed the highest tolerogenic activity, as revealed by the ability to impair the priming of IFN- -producing CD8+ T cells upon in vivo adoptive transfer. Moreover, adoptive transfer of syngeneic, GM-CSF+IL-6-conditioned MDSCs to diabetic mice transplanted with allogeneic pancreatic islets resulted in long term acceptance of the allograft and correc

ORGANISM(S): Mus musculus

DISEASE(S): 4T1 tumor-bearing

SUBMITTER: Enzo Bronte 

PROVIDER: E-GEOD-21927 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress