DosR-regulon genes induction in Mycobacterium bovis BCG under aerobic conditions
Ontology highlight
ABSTRACT:
ORGANISM(S): Mycobacterium tuberculosis
SUBMITTER: Mario Flores Valdez
PROVIDER: E-GEOD-21932 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
DosR-regulon genes induction in Mycobacterium bovis BCG under aerobic conditions.
Flores Valdez Mario Alberto MA Schoolnik Gary K GK
Tuberculosis (Edinburgh, Scotland) 20100424 3
In this report we demonstrated that under aerobic conditions, Mycobacterium bovis BCG expressing an hsp60-driven second copy of the hypoxia-related transcriptional regulator DosR increased 2-fold or greater the expression of 38 out of the 48 genes belonging to the DosR regulon, including the latency antigens Rv1733c, Rv2029, Rv2627, and Rv2628. Expression of DosR under these conditions slightly delayed in vitro growth, but did not promote a non-replicating state as opposed to microaerobic and hy ...[more]
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