Phosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (ChIP-seq)

ABSTRACT: The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of cellular response pathways. The molecular mechanisms that discriminate between the distinct p53-responses towards different stress treatments have remained largely elusive. Here, we have analyzed the p53-regulated pathways induced by two chemotherapeutical treatments, Actinomycin D inducing growth arrest and Etoposide resulting in apoptosis. We found that the genome-wide p53-binding patterns are almost identical upon both treatments notwithstanding transcriptional differences that we observed in genome-wide transcriptome analysis. To assess the role of post-translational modifications in target gene choice and activation we investigated the extent of phosphorylation of Serine 46 of p53 bound to

ORGANISM(S): Homo sapiens

SUBMITTER: Marion Lohrum 

PROVIDER: E-GEOD-21939 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress