Characterization of pathogen specific expression of host immune response genes in Mycobacterium and Anaplasma spp. infection in ruminants

ABSTRACT: Anaplasma and Mycobacterium species are known to modify gene expression in ruminants. The objectives of this study were (a) to characterize global gene expression profiles in European red deer (Cervus elaphus) in response to Anaplasma ovis and A. ovis/Mycobacterium bovis/M. avium sub. paratuberculosis (MAP) infections, (b) to compare the expression of immune response genes between A. ovis- and A. ovis/M. bovis/MAP-infected deer, and (c) to characterize the differential expression of immune response genes identified in red deer in cattle infected with M. bovis and A. marginale. The results of this study showed that global gene differential expression in A. ovis- and A. ovis/M. bovis/MAP-infected deer results in the modification of common and pathogen-specific cellular biological processes.

ORGANISM(S): Cervus elaphus

SUBMITTER: Ruth Galindo 

PROVIDER: E-GEOD-21967 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress