Impact of G protein versus beta-arrestin-dependent signal transduction at the FSH receptor (affy_fsh_human)

ABSTRACT: affy_fsh_human - affy_fsh_human - - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G proteins and ii) a newly discovered beta-arrestin-dependent pathway. The fundamental issue of the respective impacts that these two transduction mechanisms exert on gene regulation has not been clearly addressed to date. To tackle this question, we have developed two mutants of the follicle stimulating hormone (FSH) receptors which do not couple to G proteins upon FSH activation but continue to recruit beta-arrestins and signal through them.-In the present study, we compare the wild-type FSH rece

ORGANISM(S): Homo sapiens

SUBMITTER: sandrine balzergue 

PROVIDER: E-GEOD-21982 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress