Nutrient-dependent regulation of gene expression in Saccharomyces cerevisiae

ABSTRACT: Fatty acid synthesis is closely linked to nutrient availability and cellular energetic status. The committed step in fatty acid synthesis is the acetyl CoA carboxylase. Eukaryotes have two genes encoding acetyl CoA carboxylases, one encoding a cytosolic enzyme and another coding for a mitochondrial enzyme. They catalyze the synthesis of malonyl CoA in the cytosol and the mitochondria, respectively. While cytosolic malonyl CoA is the precursor for fatty acid synthesis, mitochondrial malonyl CoA controls the transfer of fatty acyl group into the mitochondria by inhibiting carnitine/palmitoyl transferase activity and thus, regulates β-oxidation. In Saccharomyces cerevisiae, β-oxidation is restricted to the peroxisomes, raising the question of the function of the mitochondrial isoform (HFA1)

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Goutham Vemuri 

PROVIDER: E-GEOD-21988 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress