Peptide alarmone signalling triggers an auto-active bacteriocin necessary for genetic competence

ABSTRACT: The induction of genetic competence is a strategy used by bacteria to increase their genetic repertoire under stressful environmental conditions. Recently, Streptococcus pneumoniae has been shown to co-ordinate the uptake of transforming DNA with fratricide via increased expression of the peptide pheromone responsible for competence induction. Here, we document that environmental stress-induced expression of the peptide pheromone competence-stimulating peptide (CSP) in the oral pathogen Streptococcus mutans. We showed that CSP is involved in the stress response and determined the CSP-induced regulon in S. mutans by microarray analysis. Contrary to pneumococcus, S. mutans responds to increased concentrations of CSP by cell lysis in only a fraction of the population. We have focused on the m

ORGANISM(S): Streptococcus mutans UA159

SUBMITTER: Chun-Hua Wan 

PROVIDER: E-GEOD-22019 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress