Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination

ABSTRACT: The myelin sheaths that surround the thick axons of the peripheral nervous system are produced by the highly specialized Schwann cells. Differentiation of Schwann cells and myelination occur in discrete steps. Each of these requires coordinated expression of specific proteins in a precise sequence, yet the regulatory mechanisms controlling protein expression during these events are incompletely understood. Here we report that Schwann cell-specific ablation of the enzyme Dicer1, which is required for the production of small non-coding regulatory microRNAs, fully arrests Schwann cell differentiation, resulting in early postnatal lethality. Dicer-/- Schwann cells had lost their ability to myelinate, yet were still capable of sorting axons. Both cell death and, paradoxically, proliferation of

ORGANISM(S): Mus musculus

SUBMITTER: Hubert Rehrauer 

PROVIDER: E-GEOD-22023 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress