Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiling of gastroesophageal adenocarcinoma

ABSTRACT: We aimed to genetically characterize adenocarcinomas in the gastroesophagel junction in relation to cancers in the esophagus and the stomach. In total 27 tumors was genetically profiled using gene expression array. Adenocarcinomas located in the gastroesophageal junction showed strong similarites with tumors in the distal esophagus, whereas different profiles were generated for tumors in the proximal stomach. Three types of gastroesophageal adenocarcinomas; 10 distal esophageal (EA) tumors, 9 junctional (JA) and 8 proximal stomach cancers (GA) was undergone differentially analysis based on gene expression profiles. One replicate of tumor ID 27_JA (replicate ID 27_JA_2) and one replicate of tumor ID 3-GA (replicate ID 3-GA-2). Reference samples consist of the Stratagene Universal Reference (10 cellines), commercially obtained from Stratagene, La Jolla, CA, USA.

ORGANISM(S): Homo sapiens

SUBMITTER: Anna Ekstrand 

PROVIDER: E-GEOD-22050 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization.

Isinger-Ekstrand Anna A   Johansson Jan J   Ohlsson Mattias M   Francis Princy P   Staaf Johan J   Jönsson Mats M   Borg Ake A   Nilbert Mef M  

Cancer genetics and cytogenetics 20100701 2

We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative target genes were validated in an extended series. Adenocarcinomas in the distal esophagus and the g  ...[more]

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