MiR-122 as a Regulator of Mitochondrial Metabolic Gene Network in Hepatocellular Carcinoma

ABSTRACT: Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues from a cohort of 96 HCC patients in Hong Kong where hepatitis B virus (HBV) is endemic. The comprehensive analysis of the coordinate expression of miRNAs and mRNAs reveals that miR-122 is under-expressed in HCC and that it is an important regulator for normal mitochondrial metabolism. A decreased level of miR-122 leads to an increase in expression of miR-122 seed-matched genes, a loss of mitochondrial metabolic function, and a decrease in the expression of many miR-122 secondary targets. These seco

ORGANISM(S): Homo sapiens

SUBMITTER: Julja Burchard 

PROVIDER: E-GEOD-22058 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress