Protein profiling reveals five principal chromatin types in Drosophila cells

ABSTRACT: The local protein composition of chromatin is important for the regulation of transcription and other functions. By integrative analysis of genome-wide binding maps of 53 broadly selected chromatin components in Drosophila cells, we show that the genome is segmented into five principal chromatin types that are defined by unique, yet overlapping combinations of proteins, and form domains that can extend over >100 kb. We identify a novel repressive chromatin type that covers about half of the genome and lacks classic heterochromatin markers. Furthermore, transcriptionally active euchromatin consists of two distinct types that differ in molecular organization and H3K36 methylation, and regulate distinct classes of genes. Finally, we provide evidence that the different chromatin types act as g

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Bas van Steensel 

PROVIDER: E-GEOD-22069 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress