Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response (sequencing)

ABSTRACT: Effective anti-viral immunity depends on the ability of infected cells or cells triggered with virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of numerous antiviral genes. However, disproportionately strong or chronic IFN expression is a common cause of inflammatory and autoimmune diseases. Here we describe an epigenetic mechanism that determines cell-type specific differences in IFN and IFN-stimulated gene expression in response to exogenous signals. We identify di-methylation of histone H3 at lysine 9 (H3K9me2) as a suppressor of IFN and IFN-inducible antiviral gene expression. We show that levels of H3K9me2 at IFN and IFN stimulated genes (ISG) correlate inversely with the scope and amplitude of IFN and ISG expression in fibroblasts and dend

ORGANISM(S): Mus musculus

SUBMITTER: Terry Fang 

PROVIDER: E-GEOD-22102 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress