Bone morphogenetic protein-7 is a MYC target with pro-survival functions in childhood medulloblastoma

ABSTRACT: Medulloblastoma (MB) is the most common malignant brain tumor in children, among whom overexpression or amplification of MYC oncogenes has been associated with poor clinical outcome. Although the MYC functions during normal development and oncogenesis in various systems have been extensively investigated, the transcriptional targets mediating MYC effects in MB are still elusive. Their identification and roles during MB onset and progression are important and will ultimately suggest novel potential therapeutic targets. cDNA microarray analysis was used to compare the effects of overexpressing and silencing MYC on the transcriptome of a MB-derived cell line. We identified 209 genes with potential relevance to MYC-dependent cellular responses in MB. Among the MYC-responsive genes, we found me

ORGANISM(S): Homo sapiens

SUBMITTER: Stefan Zoller 

PROVIDER: E-GEOD-22139 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress