Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcriptome analysis during the time course of regeneration of the human airway mucociliary epithelium

ABSTRACT: The regeneration of the airway mucociliary epithelium involves several sequential events including migration, proliferation, polarization and final differentiation (i.e ciliogenesis). We used microarrays to detail the global programme of gene expression that occurs during regeneration and ciliogenesis of the human airway mucociliary epithelium. The four time points of regeneration of the airway epithelium (ALI-D0 which corresponds to the end of proliferation step; ALI-D7 which corresponds to the polarization step; ALI-D14 which corresponds to the onset of ciliogenesis and ALI-D21 corresponding to the terminal differentiation step) for RNA extraction and hybridization on Affymetrix microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Kevin Lebrigand 

PROVIDER: E-GEOD-22142 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Multiciliated cells lining the surface of some vertebrate epithelia are essential for various physiological processes, such as airway cleansing. However, the mechanisms governing motile cilia biosynthesis remain poorly elucidated. We identify miR-449 microRNAs as evolutionarily conserved key regulators of vertebrate multiciliogenesis. In human airway epithelium and Xenopus laevis embryonic epidermis, miR-449 microRNAs strongly accumulated in multiciliated cells. In both models, we show that miR-  ...[more]

Similar Datasets

Transcriptomics MicroRNA signature during the time course of regeneration of the human airway mucociliary epithelium
2011-06-06 | E-GEOD-22141 | biostudies-arrayexpress
Transcriptomics miRNAs high throughput sequencing profiling of regenerating human airway epithelial cells
2011-06-06 | E-GEOD-22144 | biostudies-arrayexpress
Unknown miRNAs high throughput sequencing profiling of regenerating human airway epithelial cells
2011-06-07 | GSE22144 | GEO
Unknown MicroRNA signature during the time course of regeneration of the human airway mucociliary epithelium
2011-06-07 | GSE22141 | GEO
Unknown Transcriptome analysis during the time course of regeneration of the human airway mucociliary epithelium
2011-06-07 | GSE22142 | GEO
Transcriptomics microRNAs-449 control vertebrate multi-ciliogenesis by repressing Notch signalling
2011-06-06 | E-GEOD-22147 | biostudies-arrayexpress
Unknown Single-cell RNA-seq reveals novel cell differentiation dynamics during human airway epithelium regeneration
2019-09-20 | GSE121600 | GEO
Unknown Mandatory Role of HMGA1 in Human Airway Epithelial Normal Differentiation and Post-injury Regeneration
2018-04-04 | GSE86064 | GEO
Unknown An inflammatory memory of COVID-19 in airway basal stem cells impairs mucociliary differentiation (RNA-Seq)
2023-06-01 | GSE212411 | GEO
Unknown An inflammatory memory of COVID-19 in airway basal stem cells impairs mucociliary differentiation (ATAC-Seq)
2023-06-01 | GSE212410 | GEO