Pathogenesis of hepatitis E and hepatitis C in chimpanzees: Similarities and differences

ABSTRACT: The chimpanzee is the only model other than man for investigating the pathogenesis of viral hepatitis types A through E. Studies of the host response, including microarray analyses, have relied on the close relationship between these two primate species: chimpanzee samples are commonly tested with human-based reagents. In this study, the host response to two dissimilar viruses, hepatitis E virus (HEV) and hepatitis C virus (HCV), was compared in multiple experimentally-infected chimpanzees. Affymetrix U133+2.0 human microarray chips were used to assess the entire transcriptome in serial liver biopsies obtained over the course of the infections. The comparison utilized a permutational t-test-based analysis of selected time points. More specifically, baseline samples were compared with post-

ORGANISM(S): Pan troglodytes

SUBMITTER: Claro Yu 

PROVIDER: E-GEOD-22160 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress