Immunological responses unique to virulent F. tularensis Schu4 in the mouse model of infection

ABSTRACT: Francisella tularensis is a category A select agent based on its infectivity and virulence but disease mechanisms in F. tularensis infection remain poorly understood. A murine pulmonary model of infection was therefore employed to characterize the host immune response to F. tularensis infection and to discern differences in responses to infection with the highly virulent Type A F. tularensis strain Schu4 and to the less virulent Type B live vaccine strain (LVS). Mice were infected intranasally with F. tularensis Schu4 or LVS and organ lesions were assessed 48 and 120 hours after infection. Experiments were also conducted to assess and compare the host immune response to infection using global transcriptional analysis. Mice were infected via low dose aerosol with F. tularensis Schu4 or

ORGANISM(S): Mus musculus

SUBMITTER: Luke Kingry 

PROVIDER: E-GEOD-22203 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress