MICROARRAY-BASED GENE EXPRESSION ANALYSIS OF HUMAN OSTEOBLASTS IN RESPONSE TO ROUGHNESS AND FLUORIDE TREATMENT OF TITANIUM IMPLANTS

ABSTRACT: Tissue response following implantation determines the success of the healing process. This response is not only dependent on the chemical properties of the implant surface but also by the surface topography or its roughness. Although in vitro and in vivo studies show improved results with rough- and fluoride-modified implants, the mechanisms behind these findings are still unknown. Here, we have used a two step procedure to identify novel genes related to the early cell response of primary human osteoblasts to roughness and fluoride-modified titanium implants. 217 genes were identified by microarray analysis as response genes to roughness and 198 genes as response genes to fluoride. 11 of these identified genes have been related to bone and mineralization and were further investigated by r

ORGANISM(S): Homo sapiens

SUBMITTER: Marta Monjo 

PROVIDER: E-GEOD-22217 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress