Epigenetic portraits of human breast cancers (various cell lines expression data)

ABSTRACT: Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimising treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but information is scant on the involvement of the epigenome in breast cancer and its contribution to the complexity of the disease. Here we used the Infinium Methylation Platform to profile at single-CpG resolution (over 14,000 genes interrogated) the methylomes of 119 breast tumours. It emerges that many genes whose expression is linked to the ER status are epigenetically controlled (or/ we show that the two major phenotypes of breast cancers determined by ER status are widely involving epigenetic regulatory mechanisms), offering the

ORGANISM(S): Homo sapiens

SUBMITTER: Benjamin Haibe-Kains 

PROVIDER: E-GEOD-22250 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress