Distinct signature of altered homeostasis in aging rod photoreceptors: Implications for retinal diseases

ABSTRACT: To better understand the mechanistic basis of aging and its relationship with retinal degeneration, we examined gene expression changes in aging rod photoreceptors. Rod photoreceptor cell death is a feature of normal retinal aging and is accelerated in many retinal degenerative diseases, including AMD, the leading cause of untreatable adult blindness in the United States and other western countries. To our knowledge, the examination of age-related gene expression changes in a specific neuronal cell-type is novel, and it has allowed us to identify significant age-related changes with better resolution than is possible with whole retina samples. We used flow cytometry and a transgenic mouse with GFP-tagged rod photoreceptors to purify this specific cell population, and gene expression chan

ORGANISM(S): Mus musculus

SUBMITTER: Radu Cojocaru 

PROVIDER: E-GEOD-22317 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress