Innate signature induced in human mDCs by dengue vaccine candidates

ABSTRACT: Sanofi Pasteur is developing a tetravalent YFV 17D vaccine-based chimeric dengue vaccine (TV CYD), which is currently in clinical phase 3 development. DNA microarrays were used to assess the innate gene signature in human mDCs infected with the four CYDs alone or in combination, with a wild type dengue serotype 3 virus, or with a classically attenuated serotype 3 virus (VDV3) shown to be reactogenic in humans. We observed a very reproducible signature for each of the 4 CYDs, involving stimulation of Type I IFN genes and associated genes, together with genes encoding chemokines and other mediators involved in the initiation of adaptive responses. In contrast, the wt DEN3 virus induced a predominantly inflammatory profile, while VDV3 appeared to induce a blunted response, which may have cont

ORGANISM(S): Homo sapiens

SUBMITTER: Bruno Guy 

PROVIDER: E-GEOD-22329 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress