Altered immune phenotype in peripheral blood cells of patients with scleroderma-associated pulmonary hypertension

ABSTRACT: Rationale: Pulmonary arterial hypertension is a common and potentially fatal complication of scleroderma that may involve inflammatory and autoimmune mechanisms. Alterations in the gene expression of peripheral blood mononuclear cells have been previously described in patients with pulmonary arterial hypertension. The ability to identify patients at risk for developing pulmonary hypertension would be clinically beneficial. Objective: To identify genes that are differentially expressed in peripheral blood mononuclear cells in scleroderma patients with and without pulmonary hypertension which could be used as biomarkers of disease for early diagnosis and provide insight into pathogenesis of pulmonary hypertension in at-risk populations. Methods and Results: Gene expression analysis was

ORGANISM(S): Homo sapiens

SUBMITTER: Christopher Coldren 

PROVIDER: E-GEOD-22356 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress