Primary human erythroid progenitor cells HDAC1 and HDAC2 shRNA knockdown samples

ABSTRACT: Gene expression profiling was performed on primary human erythroid progenitor cells expressing a control shRNA (luciferase), two different HDAC1 shRNAs, and two different HDAC2 shRNAs. The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year in Africa alone. Induction of fetal hemoglobin is a validated strategy to improve symptoms and complications of this disease. The development of targeted therapies has been limited by the absence of discrete druggable targets. We developed a novel bead-based strategy for the identification of inducers of fetal hemoglobin transcripts in primary human erythroid cells. A small-molecule screen of bioactive compounds identified remarkable class-associated activity among histone deacetylase (HDAC) inh

ORGANISM(S): Homo sapiens

SUBMITTER: Benjamin Ebert 

PROVIDER: E-GEOD-22366 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress